Work

Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus

Year: 2005

Type: article

Abstract: There is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine-immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine.

Source: Journal of Neuroscience Research

DOI: 10.1002/jnr.20542

Authors: Mikiya Asako, Avril G. Holt, Ronald D. Griffith, Eric D. Buras, Richard A. Altschuler

Institutions: Kansai Medical University, University of Michigan, Michigan Medicine

Language: English

Topic: Hearing, Cochlea, Tinnitus, Genetics

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Public Health Service, National Institute on Deafness and Other Communication Disorders, National Institute of General Medical Sciences