Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
Year: 2014
Type: review
Study design: Systematic Review
Abstract: BACKGROUND: Cigarette smoking has been linked with both increased and decreased risk for Alzheimer's disease (AD). This is relevant for the US military because the prevalence of smoking in the military is approximately 11% higher than in civilians. METHODS: A systematic review of published studies on the association between smoking and increased risk for AD and preclinical and human literature on the relationships between smoking, nicotine exposure, and AD-related neuropathology was conducted. Original data from comparisons of smoking and never-smoking cognitively normal elders on in vivo amyloid imaging are also presented. RESULTS: Overall, literature indicates that former/active smoking is related to a significantly increased risk for AD. Cigarette smoke/smoking is associated with AD neuropathology in preclinical models and humans. Smoking-related cerebral oxidative stress is a potential mechanism promoting AD pathology and increased risk for AD. CONCLUSIONS: A reduction in the incidence of smoking will likely reduce the future prevalence of AD.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Funders: Alzheimer's Association, Bristol-Myers Squibb Foundation, Merck Company Foundation, Abbott Laboratories, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Novartis, Roche, Wyeth, Medpace, Schering-Plough, Synarc, Elan, Innogenetics, National Institutes of Health, U.S. Food and Drug Administration, Genentech, Johnson and Johnson, GE Healthcare, National Institute on Aging, National Institute on Drug Abuse, National Institute of Biomedical Imaging and Bioengineering
Awards: UC Davis Alzheimer's Disease Core Center, G3458566866, "MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies", The Neurobiological and Neurocognitive Consequences of Chronic Cigarette Smoking, Alzheimer's Disease Neuroimaging Initiative, Prediction of cognitive decline with structural, diffusion, and perfusion MRI, The Aging Brain: Vasculature, Ischemia, and Behavior
OpenAlex ID: W2142529576