Targeted Janus Kinase-2 Inhibition Overcomes Limitations of Il6-Receptor-Alpha Blockade in Controlling Human DC-Stimulated Alloreactivity
Year: 2012
Type: article
Abstract: Graft-versus-host disease (GvHD) is a serious challenge to the success of hematopoietic stem cell transplantation. The cytokine milieu of GvHD includes IL-6, IL-12, and IL-23, favoring Th1/Th17 differentiation over that of regulatory T cells (Treg). We show that blockade of IL-6-receptor-alpha in vitro with tocilizumab (humanized Mab, 5 ug/ml) fails to alter alloreactive T cell proliferation (P = NS, n = 4), Treg expansion (8.87 v 9.90%, P = NS, n = 4), or Th1/Th17 differentiation (19 v 19.6%, 1.32 v 1.53%, P = NS, n = 3).
Authors: B.C. Betts, O. Abdel-Wahab, S.A. Curran, E.T. St. Angelo, P. Koppikar, M. Kennedy, G. Heller, R.L. Levine, J.W. Young
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2142607354