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Survival Benefit of Early Infant Antiretroviral Therapy is Compromised When Diagnosis is Delayed

Year: 2012

Type: article

Study design: Observational Study

Abstract: Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9-75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival.

Source: The Pediatric Infectious Disease Journal

DOI: 10.1097/inf.0b013e3182587796

Authors: Dalton Wamalwa, Sarah Benki-Nugent, Agnes Langat, Ken Tapia, Evelyn Ngugi, Jennifer A. Slyker, Barbra A. Richardson, Grace C. John-Stewart

Institutions: University of Nairobi, University of Washington, Fred Hutch Cancer Center

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1211141729, G1990246380, G378552126, G4349000738, G627155725, G6996712595, Pediatric HIV reservoir determinants and consequences, G917087236

OpenAlex ID: W2142607725

FWCI: 3.236

Cites: 9

Cited by: 48

Related to: 10