Work

Interactions of the Human Pathogenic Brucella Species with Their Hosts

Year: 2010

Type: review

Abstract: Brucellosis is a zoonotic infection caused primarily by the bacterial pathogens Brucella melitensis and B. abortus. It is acquired by consumption of unpasteurized dairy products or by contact with infected animals. Globally, it is one of the most widespread zoonoses, with 500,000 new cases reported each year. In endemic areas, Brucella infections represent a serious public health problem that results in significant morbidity and economic losses. An important feature of the disease is persistent bacterial colonization of the reticuloendothelial system. In this review we discuss recent insights into mechanisms of intracellular survival and immune evasion that contribute to systemic persistence by the pathogenic Brucella species.

Source: Annual Review of Microbiology

DOI: 10.1146/annurev-micro-090110-102905

Authors: Vidya L. Atluri, Mariana N. Xavier, Maarten F. de Jong, Andreas B. den Hartigh, Renée M. Tsolis

Institutions: University of California, Davis, University of Washington

Language: English

Topic: Brucella: diagnosis, epidemiology, treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, University of California, Davis, National Institute of Allergy and Infectious Diseases