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Targeting Protein Tyrosine Phosphatases for Anticancer Drug Discovery

Year: 2010

Type: article

Abstract: Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107 genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate various cellular activities essential for the initiation and maintenance of malignant phenotypes. While PTK inhibitors are now used routinely for cancer treatment, the PTP inhibitor development field is still in the discovery phase. In this article, the suitability of targeting PTPs for novel anticancer drug discovery is discussed. Examples are presented for PTPs that have been targeted for anticancer drug discovery as well as potential new PTP targets for novel anticancer drug discovery.

Source: Current Pharmaceutical Design

DOI: 10.2174/138161210791209027

Authors: Latanya M. Scott, Harshani R. Lawrence, Said M. Sebti, Nicholas J. Lawrence, Jie Wu

Institutions: University of South Florida, Moffitt Cancer Center

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Moffitt Cancer Center, National Institutes of Health, National Cancer Institute