Work

MF-EA-705.ALPHA. & MF-EA-705.BETA., New Metabolites from Microbial Fermentation of a Streptomyces sp.

Year: 2001

Type: article

Abstract: As part of an antifungal discovery program, the crude extract of a Streptomyces sp. from Ecuador, MF-EA-705, was found to display broad-spectrum antifungal activity against Candida spp.and Aspergillus spp.The extract was found to contain the known weakly-antibacterial compound actinopyrone A (1), 1} previously isolated from Streptomyces pactum.We report herein the production, isolation, structure elucidation and biological activities of two new compounds MF-EA-705a (2) and MF-EA-705£ (3).A structurally similar compound has been reported in the microbial natural product literature, NFAT-1 33 (4),2) known

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.54.1100

Authors: ASFIA QURESHI, JACOB B. MAUGER, RAUL J. CANO, JORGE L. GALAZZO, MAY D. LEE

Institutions: Microcide (United States), California Polytechnic State University, Inimex Pharmaceuticals (Canada)

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2142705397

FWCI: 0.223

Cites: 2

Cited by: 7

Related to: 10