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Hypertension, antihypertensive medication use, and breast cancer risk in the California Teachers Study cohort

Year: 2010
Type: article
Study design: Observational Study
Abstract: BACKGROUND: We investigated the association between hypertension, antihypertensive (AH) medication use, and breast cancer in a large prospective study, the California Teachers Study (CTS). METHODS: Information on history of hypertension and lifetime regular use of AH medications was collected from 114,549 women in 1995-1996. Among them, 4,151 invasive breast cancers were diagnosed between 1995 and 2006. Additional information on AH use was collected from 73,742 women in 2000-2001, and 1,714 of these women were subsequently diagnosed with breast cancer. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) for breast cancer. RESULTS: Use of AH medication for ≥5 years, when compared with no use, was associated with a modest increased risk of invasive breast cancer (RR = 1.18, 95%CI 1.02-1.36). This increased risk appeared to be confined to estrogen receptor (ER)-positive tumors (RR = 1.21, 95%CI 1.03-1.43) and pre-/peri-menopausal women (RR = 1.58, 95%CI 1.11-2.25). CONCLUSIONS: Increased risk of invasive breast cancer was observed for long-term (≥5 years) AH use, and this appeared to be confined to ER + breast cancer and younger women.
DOI: 10.1007/s10552-010-9590-x
Authors: Joan A. Largent, Leslie Bernstein, Pamela L. Horn-Ross, Sarah F. Marshall, Susan Neuhausen, Peggy Reynolds, Giske Ursin, Jason A. Zell, Argyrios Ziogas, Hoda Anton-Culver
Institutions: University of California, Irvine, University of Southern California, City Of Hope National Medical Center, City of Hope, Cancer Prevention Institute of California, Stanford Medicine, Stanford University, University of Oslo, Cancer Registry of Norway
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,890
Funders: California Department of Public Health, University of Southern California, National Institutes of Health, Centers for Disease Control and Prevention, U.S. Public Health Service, National Cancer Institute
Awards: G121795637, G1392909379, G148522456, G1883905839, Breast and Other Cancers in the California Teachers Cohort, G1932976417, G2089898225, Research and Mentoring on Energetic Factors and Cancer: Established Investigator, #14: Residual Tissue Repository to Create HIV Cancer Tumor Tissue Microrarrays , G2348368848, G2612351997, G3409930413, G3509688676, G3946782388, G4153942599, G4636760173, G529197361, G6050584259, G6718950571, G7278087418, G7507271246, G756236474, G760599220, G7767432944, G799849773, Rapid Response Surveillance Study #09-5 - Constructing Geographic Areas in GIS fo, G8385479707, G87246893
OpenAlex ID: W2142812812
FWCI: 2.849
Cites: 35
Cited by: 67
Related to: 10