Work

One‐Pot Deracemization of sec‐Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases

Year: 2013

Type: article

Abstract: Hand in hand: The title transformation was achieved using a pair of sulfatases acting through inversion and retention of configuration on opposite substrate enantiomers. Using Pseudomonas aeruginosa arylsulfatase PAS with alkylsulfatase PISA1 in one-pot leads to sec-alcohols (80 to >99 % conversion) with 91 to greater than 99 % ee.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201209946

Authors: Markus Schober, Michael Toesch, Tanja Knaus, Gernot A. Strohmeier, Bert van Loo, Michael Fuchs, Florian Hollfelder, Peter Macheroux, Kurt Faber

Institutions: University of Graz, Graz University of Technology, Austrian Centre of Industrial Biotechnology (Austria), University of Cambridge

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Austrian Federal Ministry of Economy, Family and Youth, Austrian Science Fund, Bundesministerium für Verkehr, Innovation und Technologie, Standortagentur Tirol, Biotechnology and Biological Sciences Research Council

OpenAlex ID: W2142829065

FWCI: 2.286

Cites: 44

Cited by: 30

Related to: 10