Work

Chromosomal instability and human cancer

Year: 2005

Type: article

Abstract: Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell. A major question in cancer genetics is whether genetic instability is a cause and hence a driving force of tumorigenesis. A mathematical framework for studying the somatic evolution of cancer sheds light onto the causal relations between CIN and human cancer.

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2004.1617

Author: Franziska Michor

Institution: Harvard University

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2142858220

FWCI: 0.695

Cites: 49

Cited by: 19

Related to: 10