Work

Interleukin 18 in the CNS

Year: 2010

Type: review

Abstract: Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.

Source: Journal of Neuroinflammation

DOI: 10.1186/1742-2094-7-9

Authors: Silvia Alboni, Davide Cervia, Shuei Sugama, Bruno Conti

Institutions: University of Modena and Reggio Emilia, Università degli Studi della Tuscia, Nippon Medical School, Scripps Research Institute

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,090