25-Hydroxyvitamin D Status and Change in Physical Performance and Strength in Older Adults: The Health, Aging, and Body Composition Study
Year: 2012
Type: article
Study design: Observational Study
Abstract: Low 25-hydroxyvitamin D (25(OH)D) concentrations are common among older adults and are associated with poorer physical performance and strength, but results from longitudinal studies have been inconsistent. The 25(OH)D threshold for physical performance and strength was determined, and both cross-sectional and longitudinal associations between 25(OH)D and physical performance and strength were examined, in men and women aged 71-80 years from the Health, Aging, and Body Composition Study (n = 2,641). Baseline serum 25(OH)D was measured in 1998-1999, and physical performance and strength were measured at baseline and at 2- and 4-year follow-up. Piecewise regression models were used to determine 25(OH)D thresholds. Linear regression and mixed models were used to examine cross-sectional and longitudinal associations. The 25(OH)D thresholds were 70-80 nmol/L for physical performance and 55-70 nmol/L for strength. Participants with 25(OH)D <50 nmol/L had poorer physical performance at baseline and at 2- and 4-year follow-up than participants with 25(OH)D ≥75 nmol/L (P < 0.01). Although physical performance and strength declined over 4 years of follow-up (P < 0.0001), in general, the rate of decline was not associated with baseline 25(OH)D. Older adults with low 25(OH)D concentrations had poorer physical performance over 4 years of follow-up, but low 25(OH)D concentrations were not associated with a faster rate of decline in physical performance or strength.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kws147
Institutions: Wake Forest University Health Sciences, Wake Forest University, University of Georgia, University of Pittsburgh, University of California, San Francisco, California Pacific Medical Center, University of Tennessee Health Science Center, Vrije Universiteit Amsterdam, National Institutes of Health
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G100949702, Peripheral nerve decline: an underappreciated cause of injurious falls, Vitamin D, falls, fractures and function in community-dwelling older adults, End of Life in the Very Old, G670738241, Vitamin D status, related gene polymorphisms, and physical function in elders, G861947890, Wake Forest Claude D. Pepper OAIC - Renewal
OpenAlex ID: W2143206621