Work

Vaccination with LiveEscherichia coliExpressingBrucella abortusCu/Zn Superoxide Dismutase Protects Mice against VirulentB. abortus

Year: 1999

Type: article

Abstract: Vaccination of mice with Escherichia coli expressing Brucella Cu/Zn superoxide dismutase (SOD) [E. coli(pBSSOD)] induced a significant level of protection against virulent Brucella abortus challenge, although this level was not as high as the one reached with B. abortus vaccine strain RB51. In addition, vaccination with E. coli(pBSSOD) induced antibodies to Cu/Zn SOD and a strong proliferative response of splenocytes when stimulated in vitro with a thioredoxin-Cu/Zn SOD fusion protein.

Source: Infection and Immunity

DOI: 10.1128/iai.67.2.986-988.1999

Authors: Angel A. Oñate, Ramesh Vemulapalli, Edilia Andrews, Gerhardt G. Schurig, Stephen Boyle, Hugo Folch

Institutions: University of Concepción, Virginia–Maryland College of Veterinary Medicine, Virginia Tech, Austral University of Chile

Language: English

Topic: Brucella: diagnosis, epidemiology, treatment

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2143212931

FWCI: 11.61

Cites: 14

Cited by: 86

Related to: 10