Work

Cytokine, activation marker, and chemokine receptor expression by individual CD4+ memory T cells in rheumatoid arthritis synovium

Year: 2000

Type: article

Abstract: In RA large numbers of CD4 + memory T cells infiltrate the inflamed synovium [ 1 , 2 , 3 ]. The accumulated CD4 + memory T cells in the RA synovium appear to be activated, because they express cytokines and activation markers [ 4 , 5 , 6 , 7 , 8 ]. Expressed cytokines and activation markers should play important roles in the pathogenesis of RA. However, the frequency of cytokine expression by RA synovial CD4 + T cells has not been analyzed accurately. Recently, the roles of chemokine and chemokine receptor interactions in T-cell migration have been intensively examined. Interactions of chemokine and chemokine receptors might therefore be important for the accumulation of the T cells in the RA synovium. Accordingly, correlation of cytokine and chemokine receptor expression might be important in delineating the function and potential means of accumulation of individual CD4 + memory T cells in the RA synovium.

Source: Arthritis Research & Therapy

DOI: 10.1186/ar120

Authors: Toshihiro Nanki, Peter E Lipsky

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,690