Work

Roles of LIM kinases in central nervous system function and dysfunction

Year: 2015

Type: review

Abstract: LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. We finally present the existence of a cofilin-independent pathway also involved in neuronal function. A better understanding of the differences between both LIMKs and of the precise molecular mechanisms involved in their mode of action and regulation is now required to improve our understanding of the physiopathology of the neuronal diseases associated with LIMKs.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2015.10.032

Authors: H. Cuberos, B. Vallée, P. Vourc'h, J. Tastet, C.R. Andres, H. Bénédetti

Institutions: Université de Tours, Centre National de la Recherche Scientifique, Inserm, Centre de Biophysique Moléculaire, Centre Hospitalier Universitaire de Tours, University Medical Center Utrecht

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Institut National de la Santé et de la Recherche Médicale, Ligue Contre le Cancer, Ministère de l'Enseignement Supérieur et de la Recherche, Centre National de la Recherche Scientifique, Université François-Rabelais

OpenAlex ID: W2143519804

FWCI: 0.448

Cites: 174

Cited by: 55

Related to: 10