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Chemerin reveals its chimeric nature

Year: 2008

Type: article

Abstract: Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20081736

Authors: Teizo Yoshimura, Joost J. Oppenheim

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2143695755

FWCI: 4.155

Cites: 28

Cited by: 120

Related to: 10