Year: 2012
Type: article
Study design: Observational Study
Abstract: HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++ CD8+ T cells are a tissue-infiltrating population that produce IL17A, IL22, IFN, and TNFα, cytokines important in mucosal immunity. In adults they dominantly express the semi-invariant TCR Vα7.2, the canonical feature of mucosal associated invariant T (MAIT) cells and have been recently implicated in host defense against pathogens. We analyzed the frequency and function of CD161++ /MAIT cells in peripheral blood and tissue from patients with early stage or chronic-stage HIV infection. We show that the CD161++ /MAIT cell population is significantly decreased in early HIV infection and fails to recover despite otherwise successful treatment. We provide evidence that CD161++ /MAIT cells are not preferentially infected but may be depleted through diverse mechanisms including accumulation in tissues and activation-induced cell death. This loss may impact mucosal defense and could be important in susceptibility to specific opportunistic infections in HIV.
Source: Blood
Authors: Cormac Cosgrove, James E. Ussher, Andri Rauch, Kathleen Gärtner, Ayako Kurioka, Michael H. Hühn, Krista Adelmann, Yu-Hoi Kang, Joannah R. Fergusson, Peter Simmonds, Philip Goulder, Ted H. Hansen, Julie Fox, Huldrych F. Günthard, Nina Khanna, Fiona Powrie, Alan Steel, Brian Gazzard, Rodney E. Phillips, John Frater, Holm Uhlig, Paul Klenerman
Institutions: National Institute for Health and Care Research, University of Oxford, University of Bern, University Hospital of Bern, Centre for Immunity, Infection and Evolution, Washington University in St. Louis, National Health Service, St Thomas' Hospital, King's College London, University of Zurich, University Hospital Zurich, University Hospital of Basel, Chelsea and Westminster Hospital
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Estimated APC paid: $1,692
Awards: MR1 BIOCHEMICAL FEATURES AND IMMUNOLOGICAL FUNCTIONS, Swiss HIV Cohort Study (SHCS), Immune pathways in the intestine in health and disease., G619786900, Function and specificity of T cells in persistent virus infection., Centre for Immunity, Infection and Evolution., G7262634952, Optimizing CD8+ T-cell responses against C clade HIV infection in subSaharan Afri, NIHR Senior Investigator Award, Advanced Microscopy for Chromosome and RNA Dynamics.
OpenAlex ID: W2143709477