Work

Photo‐Cross‐Linkers Incorporated into G‐Protein‐Coupled Receptors in Mammalian Cells: A Ligand Comparison

Year: 2011

Type: article

Abstract: Capturing the right ligand at the right spot: a well-balanced system for non-natural amino acid mutagenesis allows the ligand binding sites of a class II G-protein coupled receptor to be mapped and distinct binding domains to be identified for different ligands in the native environment of mammalian cells.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201102646

Authors: Irene Coin, Marilyn H. Perrin, Wylie W. Vale, Lei Wang

Institution: Salk Institute for Biological Studies

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G2882583617, Genetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegans, Biology of Neuroendocrine Peptides, Cancer Center Support Grant (CCSG)