Work

Grassypeptolides F and G, Cyanobacterial Peptides from Lyngbya majuscula

Year: 2011

Type: article

Abstract: Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the Palauan cyanobacterium Lyngbya majuscula. Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC₅₀ = 5.2 and 6.0 μM, respectively).

Source: Journal of Natural Products

DOI: 10.1021/np2005083

Authors: Wendy L. Popplewell, Ranjala Ratnayake, Jennifer A. Wilson, John A. Beutler, Nancy H. Colburn, Curtis J. Henrich, James B. McMahon, Tawnya C. McKee

Institutions: Center for Cancer Research, National Cancer Institute, Science Applications International Corporation (United States)

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, U.S. Public Health Service, National Cancer Institute

Awards: G3112995819, G386607036, G5888954722, G6374948078

OpenAlex ID: W2143806820

FWCI: 2.342

Cites: 18

Cited by: 29

Related to: 10