Work

Oligonucleotide Delivery by Cell‐Penetrating “Striped” Nanoparticles

Year: 2011

Type: article

Abstract: Gold nanoparticles coated with homogeneous (MUS) or “striped” (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201104514

Authors: Christopher M. Jewell, Jin‐Mi Jung, Prabhani U. Atukorale, Randy P. Carney, Francesco Stellacci, Darrell J. Irvine

Institutions: Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology, École Polytechnique Fédérale de Lausanne, Howard Hughes Medical Institute

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Howard Hughes Medical Institute