Work

The Buccaneer software for automated model building. 1. Tracing protein chains

Year: 2006

Type: article

Abstract: A new technique for the automated tracing of protein chains in experimental electron-density maps is described. The technique relies on the repeated application of an oriented electron-density likelihood target function to identify likely C(alpha) positions. This function is applied both in the location of a few promising ;seed' positions in the map and to grow those initial C(alpha) positions into extended chain fragments. Techniques for assembling the chain fragments into an initial chain trace are discussed.

Source: Acta Crystallographica Section D Biological Crystallography

DOI: 10.1107/s0907444906022116

Author: Kevin Cowtan

Institution: University of York

Language: English

Topic: Enzyme Structure and Function

Subfield: Structural Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,740

Funders: Royal Society, Biotechnology and Biological Sciences Research Council