The “Complex‐in‐a‐Complex” Cations [(acac)2M⊂Ru6(p‐iPrC6H4Me)6(tpt)2(dhbq)3]6+: A Trojan Horse for Cancer Cells
Year: 2008
Type: article
Abstract: The start of an odyssey? The cytotoxicities of the large cationic arene–ruthenium prismatic cage 16+, and its “complex-in-a-complex” derivatives [(acac)2M⊂1]6+ (M=Pd, Pt; acac=acetylacetonate; see picture), are evaluated in comparison with free [M(acac)2]. The differences in cytotoxicity suggest that, like a “Trojan Horse”, leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect.
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2144114672