Two Quantitative Trait Loci Influence Whipworm(Trichuris trichiura)Infection in a Nepalese Population
Year: 2008
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Whipworm (Trichuris trichiura) infection is a soil-transmitted helminth infection that affects >1 billion people. It is a serious public health problem in many developing countries and can result in deficits in growth and cognitive development. In a follow-up study of significant heritability for whipworm infection, we conducted the first genome scan for quantitative trait loci (QTL) influencing the heritability of susceptibility to this important parasitic disease. METHODS: Whipworm egg counts were determined for 1,253 members of the Jirel population of eastern Nepal. All individuals in the study sample belonged to a single pedigree including >26,000 pairs of relatives that are informative for genetic analysis. RESULTS: Linkage analysis of genome scan data generated for the pedigree provided unambiguous evidence for 2 QTL influencing susceptibility to whipworm infection, one located on chromosome 9 (logarithm of the odds ratio [LOD] score, 3.35; genomewide P = .0138) and the other located on chromosome 18 (LOD score, 3.29; genomewide P = .0159). There was also suggestive evidence that 2 loci located on chromosomes 12 and 13 influenced whipworm infection. CONCLUSION: The results of this first genome scan for T. trichiura egg counts provides new information on the determinants of genetic predisposition to whipworm infection.
DOI: 10.1086/533493
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: G140538419, Quantitative Trait Locus Mapping in Human Pedigrees, G2169778925, G2352500511, G2524895636, EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION, Genetics of Susceptibility to Helminthic Infection, A GENOME SCAN FOR SUSCEPTIBILITY TO HELMINTHIC INFECTION, G518778165, G6253890364, MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION, G7852197243, QUANTITATIVE TRAIT LOCUS MAPPING IN HUMAN PEDIGREES, G9000054199
OpenAlex ID: W2144263689