Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes
Year: 2012
Type: review
Study design: Observational Study
Abstract: Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals with T2D. The current study included 1,005 men and 1,299 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, of whom 732 developed CVD. A genetic predisposition score was calculated on the basis of 29 established blood pressure-associated variants. The genetic predisposition score showed consistent associations with risk of CVD in men and women. In the combined results, each additional blood pressure-increasing allele was associated with a 6% increased risk of CVD (odds ratio [OR] 1.06 [95% CI 1.03-1.10]). The OR was 1.62 (1.22-2.14) for risk of CVD comparing the extreme quartiles of the genetic predisposition score. The genetic association for CVD risk was significantly stronger in patients with T2D than that estimated in the general populations by a meta-analysis (OR per SD of genetic score 1.22 [95% CI 1.10-1.35] vs. 1.10 [1.08-1.12]; I² = 71%). Our data indicate that genetic predisposition to high blood pressure is associated with an increased risk of CVD in individuals with T2D.
Source: Diabetes
DOI: 10.2337/db12-0225
Authors: Qibin Qi, John P. Forman, Majken K. Jensen, Alan Flint, Gary C. Curhan, Eric B. Rimm, Frank B. Hu, Lu Qi
Institutions: Harvard University, Brigham and Women's Hospital
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Awards: G150102659, G151562090, Genetic Markers of CHD in Type 2 Diabetes, Biochemical Markers in the nurses' Health Study Cohort, G2750880407, Genes and Environment Initiatives in Type 2 Diabetes, Biochemical and Genetic Markers of Type 2 Diabetes Risk, Boston Nutrition Obesity Research Center, Dietary and Hormonal Determinants of Cancer in Women, Genetics of Coronary Artery Disease in Type 2 Diabetes, G459566519, Epidemiology of Precursors to Type 2 Diabetes, G5869775930, G588599347, G7552017953, Biochemical Markers in the Nurses? Health Study Cohort, G772621625, G83951392, RISK FACTORS FOR CVD IN WOMEN, Risk Factors for Ischemic Stroke in Women, G985071772
OpenAlex ID: W2144360979