Year: 2012
Type: review
Abstract: Impaired insulin signaling is central to development of the metabolic syndrome and can promote cardiovascular disease indirectly through development of abnormal glucose and lipid metabolism, hypertension, and a proinflammatory state. However, insulin's action directly on vascular endothelium, atherosclerotic plaque macrophages, and in the heart, kidney, and retina has now been described, and impaired insulin signaling in these locations can alter progression of cardiovascular disease in the metabolic syndrome and affect development of microvascular complications of diabetes mellitus. Recent advances in our understanding of the complex pathophysiology of insulin's effects on vascular tissues offer new opportunities for preventing these cardiovascular disorders.
Authors: Christian Rask-Madsen, C. Ronald Kahn
Institutions: Joslin Diabetes Center, Harvard University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Role of PI 3-Kinase Isoforms in Insulin Action, Reversible Mitochondrial Protein Acetylation and Metabolic Regulation, Insulin Receptor Structure and Turnover, Insulin Receptor Structure and Turnover, G2810564815, The role of PKCepsilon in diabetic retinopathy, Insulin Receptor Substrates and Insulin Action, Developmental genes, miRNAs and adipose tissue
OpenAlex ID: W2144411635