Work

Multipotent Adult Progenitor Cells (MAPC) are non-immunogenic and display immunosuppressive properties on activated T cells

Year: 2006

Type: article

Abstract: Multipotent Adult Progenitor cells (MAPC) are nonhematopoietic stem cells, present within the bone marrow that can be grown extensively and can be induced to generate cells with phenotypic characteristics and gene profile of cells derived from endoderm, ectoderm and mesoderm. The capacity to differentiate into these diverse cell types distinguishes MAPC from Mesenchymal Stem Cells (MSC), and suggests that MAPCs may therefore be an ideal cell for in vivo therapies for tissue repair or regeneration in multiple organ systems (Jiang Y et al Nature, 2002; 418:41–49).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.522

Authors: M. Kovacsovics-Bankowski, P.R. Streeter, W.J. Van’t Hof, R.J. Deans, R.T. Maziarz

Institutions: Oregon Health & Science University, Athersys (United States)

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650