Work

Characterization of the Naturally Occurring Oxacillinase ofAcinetobacter baumannii

Year: 2005

Type: article

Abstract: A chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. beta-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.49.10.4174-4179.2005

Authors: Claire Héritier, Laurent Poirel, Pierre-Edouard Fournier, Jean-Michel Claverie, Didier Raoult, Patrice Nordmann

Institutions: Assistance Publique – Hôpitaux de Paris, Bicêtre Hospital, Centre National de la Recherche Scientifique, Laboratoire Information Génomique et Structurale

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2144469570

FWCI: 12.66

Cites: 35

Cited by: 300

Related to: 9