Work

Parents of High Risk Subjects Defined by Levels of Monoamine Oxidase Activity

Year: 1980

Type: article

Abstract: Thirty-seven parents of probands with low platelet monoamine oxidase (MAO) activity levels and 38 parents of high MAO probands were examined for MAO activity, past and present psychopathology, and reported psychopathology in other relatives. Results showed generally positive and significant correlations between parents' and children's MAO levels, significantly greater rates of "high MAO related" disorders in parents and relatives of high MAO probands and of "low MAO related" disorders and symptoms in parents and relatives of low MAO probands. Support for a two-directional monoamine hypothesis of affective disorders is suggested.

Source: Schizophrenia Bulletin

DOI: 10.1093/schbul/6.2.338

Authors: L. B. Puchall, R. D. Coursey, M. S. Buchsbaum, D. L. Murphy

Institutions: Fairfax County Public Schools, University of Maryland, College Park, National Institute of Mental Health

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Mental Health