Work

Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications

Year: 2009

Type: article

Abstract: Click to view: Glycopolymers can be used to display glycans on microarrays in native-like architectures. The structurally uniform alkyne-terminated mucin mimetic glycopolymers (see picture; TR = fluorophore) were printed on azide-functionalized chips by microcontact printing in the presence of a copper catalyst. The surface-bound glycopolymers bind lectins in a ligand-specific manner.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200805756

Authors: Kamil Godula, David Rabuka, Ki Tae Nam, Carolyn R. Bertozzi

Institutions: Lawrence Berkeley National Laboratory, Molecular Foundry, University of California, Berkeley, Howard Hughes Medical Institute

Language: English

Topic: Polymer Surface Interaction Studies

Subfield: Surfaces, Coatings and Films

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, U.S. Public Health Service, National Institute of General Medical Sciences

Awards: G1206721254, G2582591892, Chemical Cell Surface Engineering