Work

Molecular identification by generating coherence between molecular normal modes using stimulated Raman scattering

Year: 2009

Type: article

Abstract: We propose a method of driving the vibrations of normal modes of a target molecule into coherence using stimulated Raman scattering. In concert many vibrations can produce a larger anti-Stokes signal than a single vibration. The same illumination does not drive other molecules to have coherent vibrations so that these molecules produce a weaker signal. We investigate how target and confounder molecules can be distinguished by pulses that drive many vibrations coherently, which has applications in coherent Raman microspectroscopy.

Source: Optics Letters

DOI: 10.1364/ol.34.001756

Authors: Daniel L. Marks, Joseph B. Geddes III, Stephen A. Boppart

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign

Awards: G2362271019, Nonlinear Interferometric Vibrational Imaging of Cancer