Work

Interleukin 1 stimulation of collagenase production by cultured fibroblasts.

Year: 1983

Type: article

Abstract: Interleukin 1 is a monokine that exerts biological effects on a variety of target cells in vitro. In this report, interleukin 1 has been found to be capable of stimulating collagenase production by cultured dermal fibroblasts. The concentrations of interleukin 1 that stimulate fibroblast collagenase production are similar to those that stimulate mouse thymocyte proliferation. Analyses by high performance liquid chromatography indicate that interleukin 1, rather than a contaminating monokine, is responsible for this effect on fibroblasts. Interleukin 1, released in vivo by macrophages infiltrating sites of tissue damage or inflammation, may function to stimulate the release of collagenase by connective tissue fibroblasts.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.157.2.801

Authors: A E Postlethwaite, L B Lachman, C L Mainardi, A H Kang

Institutions: University of Tennessee Health Science Center, Veterans Health Administration, Duke Medical Center

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health