Year: 2009
Type: article
Abstract: To determine if candidate cancer biomarkers have utility in a clinical setting, validation using immunohistochemical methods is typically done. Most analyses of such data have not incorporated the multivariate nature of the staining profiles. In this article, we consider modelling such data using recently developed ideas from the machine learning community. In particular, we consider the joint goals of feature selection and classification. We develop estimation procedures for the analysis of immunohistochemical profiles using the least absolute selection and shrinkage operator. These lead to novel and flexible models and algorithms for the analysis of compositional data. The techniques are illustrated using data from a cancer biomarker study.
Source: Biomarker Insights
DOI: 10.4137/bmi.s2465
Authors: Debashis Ghosh, Ratna Chakrabarti
Institutions: Pennsylvania State University, University of Central Florida
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,650
OpenAlex ID: W2144836230