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An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

Year: 2012

Type: article

Abstract: A rapid and efficient organocatalytic cascade sequence for the direct construction of spirocyclopentane bioxindoles has been carried out by using a chiral squaramide catalyst in the presence of a base. This process constitutes a powerful approach to the preparation of biologically important bispirooxindoles in high enantioselectivities (see scheme).

Source: Chemistry - A European Journal

DOI: 10.1002/chem.201200478

Authors: Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong, Rui Wang

Institution: Lanzhou University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Natural Science Foundation of China

OpenAlex ID: W2144852976

FWCI: 11.62

Cites: 83

Cited by: 165

Related to: 10