Work

Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings

Year: 2015

Type: article

Abstract: Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing adventitious movements. Recent physiological studies have shown that cerebellar outputs are modified by release or facilitation of Purkinje cell-mediated inhibition on dentate neurons. We believe that asthenia and adventitiousness, which correlate with deficits in the control of disinhibition and inhibition, respectively, deserve more attention in clinical examination.

Source: Cerebellum & Ataxias

DOI: 10.1186/s40673-015-0033-z

Authors: Takahiro Ishikawa, Shinji Kakei, Hiroshi Mitoma

Institutions: Tokyo Metropolitan Institute of Medical Science, Tokyo Medical University

Language: English

Topic: Neurology and Historical Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,090