Work

Cancer stem cell and stromal microenvironment.

Year: 2013

Type: article

Abstract: BACKGROUND: Chemotherapeutic resistance and local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional cancer treatments do not consistently prevent cancer recurrence. METHODS: We illustrate the key roles that cancer stem cells and the tumor microenvironment-particularly the lymph node stromal microenvironment-play in tumor drug resistance, metastasis, and recurrence in 2 representative cancers: colorectal cancer and follicular lymphoma. CONCLUSION: We believe that combination treatment with chemotherapeutic agents in conjunction with targeted therapies, such as stromal/cancer stem cell signaling-targeted therapy, may effectively minimize cancer recurrence.

Source: Europe PMC (PubMed Central)

Authors: Li Li, John Cole, David A Margolin

Institutions: The University of Queensland, Ochsner Medical Center

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Award: Stromal Cell Molecules Required for Lymphoma Generation