Year: 2005
Type: review
Abstract: IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-kappaB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-kappaB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-kappaB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.
DOI: 10.1172/jci26322
Authors: J.-L. Luo, Hideaki Kamata, Michael Karin
Institution: University of California San Diego
Language: English
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Awards: G2407524486, INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME , Functions and Mechanisms of Radiation Induced Responses, Regulation of NF-kappaB and IKK by proinflammatory stimuli, G6783820451, G9000101246, G9000141551, NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
OpenAlex ID: W2145028653