Work

Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice

Year: 1973

Type: article

Abstract: A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1-1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.137.5.1142

Authors: Ralph M. Steinman, Zanvil A. Cohn

Institution: Rockefeller University

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: U.S. Public Health Service