Work

Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins

Year: 1982

Type: article

Abstract: Berberine, an alkaloid from the plant Berberis aristata, which has been known since ancient times as an antidiarrheal medication in India and China, inhibited by approximately 70% the secretory responses of the heat-labile enterotoxins of Vibrio cholerae and Escherichia coli in the rabbit ligated intestinal loop model. The drug was effective when given either before or after enterotoxin binding and when given either intraluminally or parenterally; it did not inhibit the stimulation of adenylate cyclase by cholera enterotoxin and caused no histological damage to intestinal mucosa. Berberine also markedly inhibited the secretory response of E. coli heat-stable enterotoxin in the infant mouse model. Although the mechanism of action of the drug is not yet known, these data provide a rationale for its apparent clinical usefulness in treating acute diarrheal disease.

Source: Infection and Immunity

DOI: 10.1128/iai.35.2.471-475.1982

Authors: R B Sack, J L Froehlich

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins Hospital

Language: English

Topic: Berberine and alkaloids research

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Johns Hopkins University, U.S. Army Medical Research and Development Command