Work

Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain

Year: 2009

Type: review

Abstract: Nitric oxide synthases belong to a family of dual-flavin enzymes that transfer electrons from NAD(P)H to a variety of heme protein acceptors. During catalysis, their FMN subdomain plays a central role by acting as both an electron acceptor (receiving electrons from FAD) and an electron donor, and is thought to undergo large conformational movements and engage in two distinct protein-protein interactions in the process. This minireview summarizes what we know about the many factors regulating nitric oxide synthase flavoprotein domain function, primarily from the viewpoint of how they impact electron input/output and conformational behaviors of the FMN subdomain.

Source: FEBS Journal

DOI: 10.1111/j.1742-4658.2009.07120.x

Authors: Dennis J. Stuehr, Jesús Tejero, Mohammad M. Haque

Institution: Cleveland Clinic Research

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences