Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
Year: 2008
Type: article
Study design: Observational Study
Abstract: It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD (total N = 278). Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LOD-score of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2.
DOI: 10.1002/ajmg.b.30817
Institutions: Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of North Carolina at Chapel Hill, QIMR Berghofer Medical Research Institute, Dutch Research Council, ZonMw, The Dutch Organisation for knowledge and innovation in health, healthcare and well-being, University of New England, UNSW Sydney, St Vincent's Hospital Sydney, Leiden University Medical Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Hersenstichting, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute on Alcohol Abuse and Alcoholism, National Heart, Lung, and Blood Institute, National Institute of Mental Health
Awards: G1151563582, G1311351439, G1409398652, G16286648, G178382592, Genetic Epideniologic Models of Alcohol Abuse, G2563833389, GENETIC AND EPIDEMIOLOGICAL MODELS OF ALCOHOL ABUSE, G4599390081, G4612575714, G5736797559, GENE MAPPING FOR QUANTITATIVE TRAITS, G625306055, G626177176, G7083800363, PERSISTENCE AND CHANGE IN DRINKING HABITS--TWIN STUDY, G9000311828, G961365294, G977574824
OpenAlex ID: W2145192862