Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood.
Year: 1996
Type: article
Abstract: he prevalence and severity of allergic diseases, in particular those affecting the respiratory system, are increasing at an alarming rate in the developed countries, and the international research effort into the etiology and pathogenesis of these syndromes is rapidly expanding to meet this challenge. The immunoinflammatory reactions that mediate airway tissue damage in allergic (atopic) subjects stem from aberrant T cell responses to a range of airborne environmental antigens that seemingly are ignored by non-atopic individuals. At the T cell level, allergic reactivity manifests as production of a Th-2-1ike cytokine profile at each challenge (1, 2), and mounting evidence (reviewed briefly below) suggests that the development of this pattern of T cell sensitization is frequently associated with exposure to high levels of the relevant antigens during early
Author: P G Holt
Institution: The Kids Research Institute Australia
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2145236284