Work

IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes

Year: 2009

Type: review

Abstract: Recent genome-wide association (GWA) studies of type 2 diabetes (T2D) have implicated IGF2 mRNA-binding protein 2 (IMP2/IGF2BP2) as one of the several factors in the etiology of late onset diabetes. IMP2 belongs to a family of oncofetal mRNA-binding proteins implicated in RNA localization, stability, and translation that are essential for normal embryonic growth and development. This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2 and T2D.

Source: Journal of Molecular Endocrinology

DOI: 10.1677/jme-09-0016

Authors: Jan Christiansen, Astrid M Kolte, Thomas v O Hansen, Finn C Nielsen

Institutions: University of Copenhagen, Rigshospitalet

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Kræftens Bekæmpelse, Novo Nordisk, H. Lundbeck A/S