Work

Malignant Melanoma Masquerading as an Angiofibroma in a Patient With MEN-1

Year: 2014

Type: article

Abstract: Multiple endocrine neoplasia type 1 (MEN-1) is an autosomal dominant syndrome consisting of endocrine tumors of the parathyroid gland, pituitary gland, and pancreas. MEN-1 is caused by loss of function mutations in the MEN1 gene, which encodes the tumor suppressor protein menin. Cutaneous collagenomas and facial angiofibromas also have been associated with MEN-1 and may serve as diagnostic clues to the diagnosis. We present a case of amelanotic melanoma resembling a large angiofibroma in a young man with MEN-1.

Source: JAMA Dermatology

DOI: 10.1001/jamadermatol.2014.2186

Authors: G. Thomas Brown, Edward W. Cowen, Chyi-chia Richard Lee

Institutions: National Institutes of Health, National Cancer Institute

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute