Work

Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars

Year: 2009

Type: article

Abstract: Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200806319

Authors: Pamela V. Chang, Xing Chen, Chris Smyrniotis, Alexander Xenakis, Tianshun Hu, Carolyn R. Bertozzi, Peng Wu

Institutions: Howard Hughes Medical Institute, Lawrence Berkeley National Laboratory, Molecular Foundry, University of California, Berkeley, Albert Einstein College of Medicine, Yeshiva University

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, U.S. Public Health Service, National Institute of General Medical Sciences

Awards: Metabolic Engineering with Bioorthogonal Chemical Reporters, G2370309056, Applications of Click Chemistry in Glycobiology, Applications of Click Chemistry in Glycobiology

OpenAlex ID: W2145468405

FWCI: 6.375

Cites: 30

Cited by: 228

Related to: 10