Work

Identification of the target self-antigens in reperfusion injury

Year: 2006

Type: article

Abstract: Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20050390

Authors: Ming Zhang, Elisabeth M. Alicot, Isaac Chiu, Jinan Li, Nicola Verna, Thomas Vorup-Jensen, Benedikt Kessler, Motomu Shimaoka, Rodney Chan, Daniel Friend, Umar Mahmood, Ralph Weissleder, Francis D. Moore, Michael C. Carroll

Institutions: DecImmune Therapeutics (United States), Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Reperfusion Injury Therapy: Role for IgM Antibody, Augmented Injury due to Autologous Inflammatory Attack, G7348176165

OpenAlex ID: W2145472609

FWCI: 13.81

Cites: 58

Cited by: 223

Related to: 9