Work

Transport of Intact Porphyrin by HpuAB, the Hemoglobin-Haptoglobin Utilization System ofNeisseria meningitidis

Year: 1998

Type: article

Abstract: The meningococcal hemA gene was cloned and used to construct a porphyrin biosynthesis mutant. An analysis of the hemA mutant indicated that meningococci can transport intact porphyrin from heme (Hm), hemoglobin (Hb), and Hb-haptoglobin (Hp). By constructing a HemA- HpuAB- double mutant, we demonstrated that HpuAB is required for the transport of porphyrin from Hb and Hb-Hp.

Source: Journal of Bacteriology

DOI: 10.1128/jb.180.22.6043-6047.1998

Authors: L. A. Lewis, M.-H. Sung, M. Gipson, K. Hartman, D. W. Dyer

Institution: University of Oklahoma Health Sciences Center

Language: English

Topic: Bacterial Infections and Vaccines

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases