Work

GeneChip Analyses of Global Transcriptional Responses of Murine Macrophages to the Lethal Toxin ofBacillus anthracis

Year: 2005

Type: article

Abstract: We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.

Source: Infection and Immunity

DOI: 10.1128/iai.73.3.1879-1885.2005

Authors: Jason E. Comer, Cristi L. Galindo, Ashok K. Chopra, Johnny W. Peterson

Institution: The University of Texas Medical Branch at Galveston

Language: English

Topic: Bacillus and Francisella bacterial research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases