Effects of androgen supplementation therapy on partial androgen deficiency in the aging male: a preliminary study
Year: 2002
Type: article
Study design: Clinical Trial
Abstract: OBJECTIVE: To assess the responses of a symptom complex related to partial androgen deficiency in the aging male (PADAM) to androgen supplementation. SUBJECTS AND METHODS: Eighty-six men from five hospitals in Beijing aged 50-70 years with symptoms related to PADAM received oral testosterone undecanoate for 2 months, and the effects of the therapy were evaluated. RESULTS: After treatment, the symptom scores were significantly improved (all p < 0.001). Serum levels of luteinizing hormone and follicle stimulating hormone were suppressed, and free testosterone and albumin-bound testosterone levels were elevated. However, they were not significantly different from the pretreatment values. Waist/hip ratio and blood pressure were markedly decreased, but no changes were found in serum levels of total cholesterol, triglyceride, albumin and prostate specific antigen. CONCLUSIONS: Two months of treatment with oral testosterone undecanoate clearly improved the symptoms related to PADAM. No statistical relationship was found between symptom improvement and androgen levels. Androgen therapy for 2 months was beneficial to the waist/hip ratio and blood pressure, and no harm was done to the prostate gland or lipid metabolism.
Source: The Aging Male
DOI: 10.1080/713604649
Authors: J. -Y. Li, J. -C. Zhu, J. -T. Dou, W. -J. Bai, S. -M. Deng, W. Huang, H. Jin
Institution: Chinese Medical Association
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2145773566