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PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription

Year: 2012
Type: preprint
Abstract: Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1). It is required for maintenance of all levels of H4K20me, and, importantly, loss of PR-Set7 is catastrophic for the earliest stages of mouse embryonic development. These findings have placed PR-Set7, H4K20me, and proteins that recognize this modification as central nodes of many important pathways. In this review, we discuss the mechanisms required for regulation of PR-Set7 and H4K20me1 levels and attempt to unravel the many functions attributed to these proteins.
DOI: 10.1101/gad.177444.111
Institutions: Howard Hughes Medical Institute, New York University, Kyushu University, National Hospital Organization Kyushu Cancer Center, Medical Institute of Bioregulation, Kyushu University, NYU Langone Health
Language: English
Open Access status: bronze
Awards: G2096299921, Analysis of chromatin function mediated by histone H4 lysine 20 methylation, G3508580505, INITIATION OF TRANSCRIPTION OF PROTEIN CODING GENES, Initiation of Transcription of Protein Coding Genes, Repression via Facultative Heterochomatin.
OpenAlex ID: W2145869787
Cites: 101
Cited by: 344
Related to: 10