Work

Novel Florfenicol and Chloramphenicol Resistance Gene Discovered in Alaskan Soil by Using Functional Metagenomics

Year: 2010

Type: article

Abstract: Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily.

Source: Applied and Environmental Microbiology

DOI: 10.1128/aem.00323-10

Authors: Kevin S. Lang, Janet M. Anderson, Stefan Schwarz, Lynn Williamson, Jo Handelsman, Randall S. Singer

Institutions: University of Minnesota, Friedrich-Loeffler-Institut, University of Wisconsin–Madison

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Agriculture, University of Minnesota

OpenAlex ID: W2145985839

FWCI: 2.98

Cites: 38

Cited by: 86

Related to: 10